Journal
NANOSCALE
Volume 12, Issue 13, Pages 6953-6958Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr10720g
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Funding
- Training Program of the Major Research Plan of the National Natural Science Foundation of China [91959123]
- Key Research and Development Program of Social Development of Jiangsu Province [BE2018655]
- National Science Foundation of China [21572153]
- Open Project Program of the State Key Laboratory of Radiation Medicine and Protection [GZK1201819, GZK1201916]
- Advanced Research and Study Project for Higher Vocational College Academic Leaders in Jiangsu Province [2019GRFX093h]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Developing novel small-molecule-based probes with both deep tissue imaging and therapeutic functions is highly significant in cancer diagnosis and treatment. Herein, we report a novel second near-infrared (NIR-II) fluorescent probe QT-RGD constructed with a NIR-II emissive organic fluorophore and two cyclic-(arginine-glycine-aspartic acid) (cRGD) peptides that can specifically bind to the tumor-associated alpha(v)beta(3) integrin for accurate tumor diagnosis and targeting therapy. The isotopic I-125-labeled probe exhibited great tumor targeting ability and emitted intensive NIR-II/photoacoustic (PA)/single-photon emission computed tomography (SPECT) signals, which allows specific and sensitive multimodal visualization of tumors in vivo. More notably, this probe could also be applied for effective imaging-guided photothermal therapy (PTT) of tumors in mouse models owing to its prominent photothermal conversion efficiency and excellent photothermal stability. We thus envision that our work which unveils a combination of NIR-II/PA/SPECT imaging and PTT would offer a valuable means of improving tumor diagnostic accuracy as well as therapeutic efficacy.
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