Journal
NON-CODING RNA
Volume 6, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ncrna6010004
Keywords
centromere; chromosome segregation; RNP
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI [26870442, 24770168, 23112716]
- Shinnihon Foundation of Advanced Medical Treatment Research
- Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [24770168, 26870442] Funding Source: KAKEN
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Chromosome segregation is strictly regulated for the proper distribution of genetic material to daughter cells. During this process, mitotic chromosomes are pulled to both poles by bundles of microtubules attached to kinetochores that are assembled on the chromosomes. Centromeres are specific regions where kinetochores assemble. Although these regions were previously considered to be silent, some experimental studies have demonstrated that transcription occurs in these regions to generate non-coding RNAs (ncRNAs). These centromeric ncRNAs (cenRNAs) are involved in centromere functions. Here, we describe the currently available information on the functions of cenRNAs in several species.
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