Journal
JOURNAL OF ANTIBIOTICS
Volume 70, Issue 7, Pages 823-827Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2017.52
Keywords
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Funding
- Foundation for the National Natural Science Foundation of China [21462015, 21662012]
- Marine Science and Technology Program of Hainan Province [2015XH06]
- National Natural Science Foundation of Hainan Province [20152034]
- Program for Innovative Research Team in University [IRT-16R19]
- Hainan Province Natural Science Foundation of Innovative Research Team Project [2016CXTD007]
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Two new chlorinated metabolites 4-chloro-1-hydroxy-3-methoxy-6-methyl-8-methoxycarbonyl-xanthen-9-one (1) and 2'-acetoxy-7-chlorocitreorosein (2), together with three known compounds (3-5), were obtained from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their antibacterial and topoisomerase I inhibitory activities. Compound 2 exhibited antibacterial activity against Vibrio parahaemolyticus with an MIC value of 10 mu m.
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