Journal
FRONTIERS IN CARDIOVASCULAR MEDICINE
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2020.00039
Keywords
high density lipoprotein; cardiovascular risk; obesity; endothelial function; HDL-therapy; bariatric surgery; lipoproteins
Categories
Funding
- Swiss National Science Foundation [PZ00P3_161506, PR00P3_179861/1]
- Swiss Cardio-Onco-Grant Alfred and Annemarie von Sick Grant
- Hartmann Muller Foundation
- Swiss Life Foundation
- Olga Mayenfisch
- Swiss National Science Foundation (SNF) [PR00P3_179861] Funding Source: Swiss National Science Foundation (SNF)
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High Density Lipoproteins (HDLs) have long been considered as good cholesterol, beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are complex particles that undergoes dynamic remodeling through interactions with various enzymes and tissues throughout their life cycle, making the complete understanding of its functions and roles more complicated than initially expected. In this review, we explore the novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality. Further, we report on emergent HDL-based therapeutics tested in small and larger scale clinical trials and their mixed successes.
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