Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 26, Pages 3741-3744Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00377h
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Funding
- National Natural Science Foundation of China [21778009, 21977010, 81701818, 51803006]
- Shenzhen Science and Technology Innovation Committee [JCYJ20170817172023838, JCYJ20180507181527112]
- Shenzhen Kongque'' High-Level Talent Program
- Shenzhen Longhua Longwuhuazhang'' High-Level Talent Program
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Continuous efforts have been invested in the selective modification of proteins. Herein, we first report the construction of sulfonium tethered cyclic peptides via an intramolecular cyclization by an aliphatic halide. This cyclization could enhance the stability and cellular uptake of peptides. Furthermore, the sulfonium center could be recognized by cysteine in the vicinity of the protein-peptide interacting interface and form a peptide-protein conjugate.
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