4.7 Article

Unlocking the direct photocatalytic difluoromethylation of C&xe001;N bonds

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 26, Pages 3769-3772

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01353f

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Funding

  1. European Research Council (ERC-CoG) [647550]
  2. Spanish Government [RTI2018-095038-B-I00]
  3. Comunidad de Madrid
  4. European Structural Funds [S2018/NMT-4367]

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The current study presents a direct CF2H radical addition to C & xe001;N bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized.

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