Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 58, Issue 1, Pages 139-145Publisher
IOS PRESS
DOI: 10.3233/JAD-161169
Keywords
Alzheimer's disease; buccal cells; telomeres
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Funding
- Cognition Challenge (Johnson & Johnson Innovation)
- Canadian Consulate in San Francisco
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This study validates and expands on our previous work that assessed three-dimensional (3D) nuclear telomere profiling in buccal cells of Alzheimer's disease (AD) patients and non-AD controls (Mathur et al., J Alzheimers Dis 39, 35-48, 2014). While the previous study used age-and gender-matched caregiver controls, the current study consented a new cohort of 44 age-and gender-matched healthy non-caregiver controls and 44 AD study participants. 3D telomeric profiles of buccal cells of AD patients and their non-AD controls were examined with participant information blinded to the analysis. In agreement with our previous study, we demonstrate that 3D telomeric profiles allow for the distinction between AD and non-AD individuals. This validation cohort provides an indication that the total number of 3D telomeric signals and their telomere lengths may be a suitable biomarker to differentiate between AD and non-AD and between mild, moderate, and severe AD. Further studies with larger sample sizes are required to move this technology further toward the clinic.
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