Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 57, Issue 3, Pages 711-716Publisher
IOS PRESS
DOI: 10.3233/JAD-161139
Keywords
Cerebral amyloid angiopathy; cortical superficial siderosis; F-18-AV-1451 PET; lobar cerebral microbleeds; tau
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [NRF-2015R1C1A2A01 053281]
- Brain Research Program through the National Research Foundation of Korea (NRF) - the Ministry of Science, ICT & Future Planning [2016M3C7A1913844]
- Korea Ministry of Environment (MOE) as the Environmental Health Action Program [2014001360002]
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Cerebrovascular deposition of amyloid-beta, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent C-11-Pittsburgh Compound B (PiB) PET or F-18-florbetaben PET to evaluate amyloid burden, and F-18-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased F-18-AV-1451 uptake. Our preliminary study raised the possibility
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