Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 56, Issue 1, Pages 25-36Publisher
IOS PRESS
DOI: 10.3233/JAD-160889
Keywords
Alzheimer's disease; biomarker; complement; inflammation; polygenic risk score
Categories
Funding
- Wellcome Trust [082604/2/07/Z]
- French National Foundation on Alzheimer's disease and Related Disorders
- LABEX (laboratory of Excellence Program Investment for the Future) DISTALZ grant
- Inserm
- Institut Pasteur de Lille
- Universite de Lille 2
- Lille University Hospital
- Medical Research Council [MR/K013041/1]
- Alzheimer's Research UK [ARUK-Network2011-4]
- German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) [01GI0102, 01GI0711, 01GI0420]
- NIH/NIA [R01 AG033193, U01 AG032984, U24 AG021886, U01 AG016976]
- NIA [AG081220]
- AGES [N01-AG-12100]
- NHLBI [R01 HL105756]
- Icelandic Heart Association
- Erasmus Medical Center
- Erasmus University
- Alzheimer's Association [ADGC-10-196728]
- NINDS
- Welsh Assembly Government
- Alzheimer's Society
- Ulster Garden Villages
- N. Ireland RD Office
- Royal College of Physicians/Dunhill Medical Trust
- Mercer's Institute for Research on Ageing
- Bristol Research into Alzheimer's and Care of the Elderly
- Charles Wolfson Charitable Trust
- NIH
- Barnes Jewish Foundation
- Charles and Joanne Knight Alzheimer's Research Initiative
- Lundbeck SA
- German Federal Ministry of Education and Research (BMBF), Competence Network Dementia and Competence Network Degenerative Dementia
- Alfried Krupp von Bohlen und Halbach-Stiftung
- Helmholtz Zentrum Munchen
- German Research Center for Environmental Health
- German National Genome Research Network
- Munich Center of Health Sciences
- Heinz Nixdorf Foundation
- Intramural Research Program of the National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Allergy and Infectious Diseases
- National Human Genome Research Institute
- National Institute of Child Health and Human Development
- Juvenile Diabetes Research Foundation International
- MRC [G0801418, MR/N01104X/1, UKDRI-3003, MR/K013041/1, G0902227, G0300429, MR/L023784/1, G1001799, MR/L023784/2] Funding Source: UKRI
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL105756] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U24AG021886, U01AG032984, R01AG033193, U01AG016976] Funding Source: NIH RePORTER
- Alzheimers Research UK [ARUK-PG2014-1] Funding Source: researchfish
- Medical Research Council [G0902227, MR/N01104X/1, MR/L501517/1, G1001799, MR/L023784/2, MR/L023784/1, G0801418, G0300429, UKDRI-3003, G0801418B, MR/L010305/1] Funding Source: researchfish
Ask authors/readers for more resources
Plasma biomarkers to aid the early diagnosis of Alzheimer's disease (AD) or to monitor disease progression have long been sought and continue to be widely studied. Biomarkers that correlate with AD polygenic risk score, a measure of the polygenic architecture of the disease and highly predictive of AD status, would be excellent candidates. Therefore, we undertook a preliminary study to assess the association of plasma inflammatory biomarkers with an overall AD polygenic risk score as well as with an inflammation-specific AD polygenic risk score in a sample set of 93 AD cases. We measured five complement biomarkers [complement receptor 1 (CR1), clusterin, complement component 9 (C9), C1 inhibitor (C1inh), terminal complement complex (TCC)] and the benchmark inflammatory marker C-reactive protein (CRP). Plasma clusterin level showed an association with overall AD polygenic risk score, while clusterin, C1inh, and CRP levels each displayed some association with the inflammatory-specific AD polygenic risk score. The results suggest that elevated plasma levels of inflammatory biomarkers, including complement proteins, associate with polygenic risk scores in AD, further strengthening the link between genetic and biomarker disease predictors and indicating a potential role for these markers in disease prediction and patient stratification in AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available