Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 58, Issue 1, Pages 193-201Publisher
IOS PRESS
DOI: 10.3233/JAD-161158
Keywords
Amyloid load; apolipoprotein E; attention; carbohydrates; cognition; PiB PET; verbal memory
Categories
Funding
- CSIRO Flagship Collaboration Fund
- Science and Industry Endowment Fund (SIEF)
- Edith Cowan University (ECU)
- Florey Institute of Neuroscience and Mental Health
- Alzheimer's Australia (AA)
- National Ageing Research Institute (NARI)
- Austin Health
- CogState Ltd.
- Hollywood Private Hospital
- Sir Charles Gairdner Hospital
- National Health and Medical Research Council (NHMRC)
- Dementia Collaborative Research Centres program (DCRC2)
- Government of Victoria
- Curtin University Senior Research Fellowship [CRF140196]
- NHMRC [APP1045507, APP1105698]
- McCusker Alzheimer's Research Foundation
Ask authors/readers for more resources
Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) epsilon 4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-beta (A beta) load in CN older adults, genotyped for APOE epsilon 4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOE epsilon 4 allele non-carriers, and poorer performance in attention in APOE epsilon 4 allele carriers. There were no associations between carbohydrate intake and cerebral A beta load. These results provide support to the idea that decreasing carbohydrate intake may offer neurocognitive benefits, with specific cognitive domains affected in an APOE genotype-dependent manner. These findings warrant further investigation utilizing a longitudinal study design.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available