Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 27, Pages 3915-3918Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09887a
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Funding
- King Abdullah Scholarship award
- Irish Cancer Society [CRS11FER]
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Eukaryotic tRNA-guanine transglycosylase (TGT) - an enzyme recently recognised to be of potential therapeutic importance - catalyses base-exchange of guanine for queuine at the wobble position of tRNAs associated with 4 amino acids via a distinct mechanism to that reported for its eubacterial homologue. The presence of queuine is unequivocally required as a trigger for reaction between the enzyme and tRNA and exhibits cooperativity not seen using guanine as a substrate.
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