Morphofunctional parameters of blood cells of a rat with 1,2-dimethylhydrazine-induced colon carcinogenesis

The reduction of mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) whereas increasing of reticulocytes number and indirect bilirubin after 20 weeks of experiment of dimethylhydrazine (DMH)-induced colon carcinogenesis indicate the hemolysis of red blood cells due to the DMH influence during tumor development. The slight increasing of number of monocytes and platelets, as well as considerable increasing of a number of eosinophilic granulocytes, has been observed. Reduction of number of hemoglobin and erythrocytes, slight increase of number of monocytes, and significant increase in number of platelets in blood of rats follows 26 weeks of the experiment (after 6 weeks of DMH discontinuation). Anemia with thrombocytosis accompany cancer in humans and the model of DMH-induced colon cancer is appropriate not only for studies of carcinogenesis and searching of new antineoplastic drugs but also for the development of correctional approaches of cancer-associated changes in the hematopoietic system.