Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 18, Pages 2775-2778Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00300j
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Funding
- National Natural Science Foundation of China [21702237, 21272004]
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The expeditious construction of phenanthridine scaffolds via a Pd/MnO2-mediated C-H arylation/oxidative annulation cascade involving aldehydes, aryl iodides and amino acids is disclosed. This reaction proceeds smoothly involving the formation of multiple chemical bonds with the tolerance of a wide range of functional groups. The control experiments suggest a radical mechanism for C-N bond formation via MnO2-promoted oxidative annulation of imine compounds. The synthetic utility of this transformation has been demonstrated via the straightforward access to bioactive natural alkaloid trisphaeridine and its analogue.
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