Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 18, Pages 2731-2734Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09158k
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We herein develop two beta-galactosidase (beta-Gal) activatable NIR fluorescent probes for visualizing ovarian cancers. Particularly, probe BOD-M-beta Gal produced NIR-II emission light at 900-1300 nm upon beta-Gal activation. By using our activatable and target specific NIR-II probe for deep-tissue imaging of beta-Gal overexpressed ovarian cancer cells, rapid and accurate imaging of ovarian tumors in nude mice was achieved.
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