Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 26, Pages 10535-10539Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202003839
Keywords
droplet self-splitting; microarrays; multiple analyte detection; simultaneous arrayed reactions; surface chemistry
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Funding
- National Key R&D Program of China [2018YFA0208501, 2018YFA0703200]
- National Natural Science Foundation of China (NSFC) [51773206, 51573192, 51903240, 21522308, 11432008, 11772169, 91963212, 51961145102]
- Postdoctoral Innovative Talents Support Program [BX20180313]
- China Postdoctoral Science Foundation [2018M641482]
- K.C. Wong Education Foundation
- Beijing National Laboratory for Molecular Sciences [BNLMS-CXXM-202005]
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Precise separation and localization of microdroplets are fundamental for various fields, such as high-throughput screening, combinatorial chemistry, and the recognition of complex analytes. We have developed a droplet self-splitting strategy to divide an impacting droplet into predictable microdroplets and deposit them at preset spots for simultaneous multidetection. No matter exchange was observed between these microdroplets, so they could be manipulated independently. Droplet self-splitting was attributed to anisotropic liquid recoiling on the patterned adhesive surface, as influenced by the droplet Weber number and the width of the low-adhesive stripe. A quantitative criterion was also developed to judge the droplet self-splitting capability. The precise separation and distribution of microdroplets enabled simultaneous arrayed reactions and multiple analyte detection using one droplet of sample.
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