Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 26, Issue 6, Pages 615-623Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2015.07.017
Keywords
IL-33; ST2; Autoimmunity; Inflammatory bowel diseases; Table of contents
Categories
Funding
- [CONICYT130037]
- [FONDECYT1120577]
- [FONDECYT3150328]
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IL-33, an IL-1 family member, is expressed by many cell types and can regulate gene transcription. IL-33 is released upon cell necrosis and the precursor form is enzymatically processed, and then drives inflammation as a damage-associated molecular pattern. The IL-33 receptor ST2, encoded by IL1RL1, is expressed as both a membrane-anchored receptor (ST2L) activated by IL-33, and as a soluble variant (sST2) that exhibits anti-inflammatory properties. The IL-33/ST2 axis is involved in the pathogenesis of atopic and autoimmune diseases, cancer, and central nervous system disorders. Here, we review recent findings on the role of the IL-33/ST2 axis in health and disease. (C) 2015 Elsevier Ltd. All rights reserved.
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