Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 26, Issue 5, Pages 569-578Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2015.07.005
Keywords
Interleukin 23; IL-23 receptor; IL-12R beta 1; Signal transduction
Categories
Funding
- Deutsche Forschungsgemeinschaft, Bonn, Germany [SFB1116, B02]
- RCMF of the University of Dusseldorf
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Interleukin (IL-)23 is a central cytokine controlling T(H)17 development. Overshooting IL-23 signaling contribute to autoimmune diseases. Moreover, GWAS studies have identified several SNPs within the IL-23 receptor, which are associated with autoimmune diseases. IL-23 is a member of the IL-12-type cytokine family and consists of IL-23p19 and p40. Within the IL-12 family, IL-12 and IL-23 share the p40 cytokine subunit and the IL-12R beta 1 as one chain of the receptor complex. For signaling, IL-23 triggers heterodimerization of IL-12R beta 1 and the IL-23R. Subsequently, signal transduction pathways including JAK/STAT, MAPK and PI3K are activated. Most studies have investigated the biological relevance of IL-23 in the development of T(H)17 cells and autoimmunity, whereas less is known about the molecular context of IL-23 biology. Therefore, we focused on IL-23 receptor complex assembly, signal transduction and functional relevance of IL-23R SNPs in the context of IL-23-inhibitory principles. (C) 2015 Elsevier Ltd. All rights reserved.
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