Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 26, Issue 1, Pages 47-57Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.09.002
Keywords
Nuclear factor etythroid 2-related factor 2; Cerebrum actions; Molecular mechanisms; Neurodegenerative disorders
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Funding
- National Natural Science Foundation of China [81070951, 81222015, 81273100, 81100843]
- Excellent Doctoral Support Project of the Fourth Military Medical University [2013D01]
- New Century Talent Supporting Project by Chinese Education Ministry [NCET-12-1004]
- Changjiang Scholars and Innovative Research Team in University [IRT1053]
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Recently, growing evidence has demonstrated that nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal regulator of endogenous defense systems that function via the activation of a set of protective genes, and this is particularly clear in the central nervous system (CNS). Therefore, it is highly useful to summarize the current literature on the molecular mechanisms and role of Nrf2 in the CNS. In this review, we first briefly introduce the molecular features of Nrf2. We then discuss the regulation, cerebral actions, upstream modulators and downstream targets of Nrf2 pathway. Following this background, we expand our discussion to the role of Nrf2 in several major neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis. Lastly, we discuss some potential future directions. The information reviewed here may be significant in the design of further experimental research and increase the potential of Nrf2 as a therapeutic target in the future. (C) 2014 Elsevier Ltd. All rights reserved.
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