Journal
CYTOKINE
Volume 74, Issue 2, Pages 318-326Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.02.007
Keywords
B cells; Cytokines; Interleukins; Interferon; Chemokines
Funding
- NIAID NIH [R01 AI93548, R21 AI096278]
- NSF-GK-12 Grant [DGE-0638751]
- NIH MBRS-IMSD [GM055246]
- CONACYT/SEP [329416/BC-1455]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI093548, R21AI096278, R21AI117556] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R25GM055246] Funding Source: NIH RePORTER
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The adaptive immune system consists of two types of lymphocytes: T and B cells. These two lymphocytes originate from a common precursor, yet are fundamentally different with B cells mediating humoral immunity while T cells mediate cell mediated immunity. In cytokine production, na ve T cells produce multiple cytokines upon activation while na ve activated B cells do not. B cells are capable of producing cytokines, but their cytokine production depends on their differentiation state and activation conditions. Hence, unlike T cells that can produce a large amount of cytokines upon activation, B cells require specific differentiation and activation conditions to produce cytokines. Many cytokines act on B cells as well. Here, we discuss several cytokines and their effects on B cells including: Interleukins, IL-7, IL-4, IL-6, IL-10, and Interferons, IFN-alpha, IFN-beta, IFN-gamma. These cytokines play important roles in the development, survival, differentiation and/or proliferation of B cells. Certain chemokines also play important roles in B cell function, namely antibody production. As an example, we discuss CCL28, a chemokine that directs the migration of plasma cells to mucosal sites. We conclude with a brief overview of B cells as cytokine producers and their likely functional consequences on the immune response. (C) 2015 Elsevier Ltd. All rights reserved.
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