Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 33, Pages 4607-4610Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00855a
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Funding
- National Key Research and Development Program of China [2018YFA0903200/2018YFA0903201]
- National Natural Science Foundation of China [81925037, 31761143016, 81973213, 81673315]
- Chang Jiang Scholars Program (Young Scholar) from the Ministry of Education of China (Hao Gao, 2017)
- National High-level Personnel of Special Support Program [2017RA2259]
- 111 Project of Ministry of Education of the People's Republic of China [B13038]
- Guangdong Natural Science Funds for Distinguished Young Scholar [2017A03036027]
- Guangdong Special Support Program [2016TX03R280]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y036]
- Pearl River Nova Program of Guangzhou [201610010021]
- K. C. Wong Education Foundation
- high-performance computing platform of Jinan University
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Sporormielones A-E (1-5), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1-3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, C-13 labelling, and gene deletion, their plausible biosynthetic mechanism was proposed.
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