4.7 Article

A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 32, Pages 4432-4435

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00382d

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Funding

  1. National Natural Science Foundation of China [21807018]
  2. Department of Education of Guangdong Province [2018KQNCX047]
  3. project of Guangdong province [2015A040404042]
  4. Guangzhou University of Chinese Medicine [2019QNPY06]

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A new FRET probe has been prepared for ratiometric fluorescence detection of hydroxyl radicals. It has been successfully used for detecting mitochondria-localized drug activation in living cells and imaging endogenous hydroxyl radicals in zebrafish gastrointestinal (GI) tracts under normal culturing conditions.

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