Journal
RSC ADVANCES
Volume 10, Issue 25, Pages 14965-14971Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra00417k
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Analysis of UV-visible spectra, performed on commercial riboflavin-based eye drops, showed that absorbance is a saturating function of vitamin concentration. This implies a threshold concentration, C-t, such that for riboflavin concentration > C-t the absorbance remains constant and the effectiveness of the eye drops is independent of the dose used. These experimental results were combined with a diffusion-reaction model to elucidate the mechanism of action within the cornea. The model predicts that the eye drops have a low effectiveness on UVB and UVC, while they have a good performance for UVA. Indeed, at the center of the cornea the transmittance is significantly reduced and after 1 h it is reduced by about 70% compared to a cornea devoid of eye drops.
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