Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 65, Issue 2, Pages 291-300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b04597
Keywords
Prunella vulgaris L.; ethyl acetate parts of aqueous extracts from Prunella vulgaris L.; acetylcholiri esterase inhibitor; neuroprotection; chemical components
Funding
- China Postdoctoral Science Foundation [2015T81140]
- Ph.D. research startup foundation of Logistics University of Chinese People's Armed Police Forces [WHB201509]
- Science and Technology Support Program Foundation of Tianjin China [15CZDSY01020]
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Prunella vulgaris L. is as a major plant in the Chinese traditional functional beverage Guangdong herbal tea for the treatment of fevers, diarrhea, and sore mouth. In this study, ethyl acetate parts of aqueous extracts from P. vulgaris L. (EtOAc-APV) were found to demonstrate potent acetylcholinesterase (AChE) inhibition in vitro. Therefore, this study was designed to further investigate the, effects of Et0Ac-APV on scopolamine (SCOP)-induced aging rats. Male Wistar rats were randomly divided into four groups (n = 12) and given orally by gavage EtOAc-APV (100 mg/kg) for 3 weeks. SCOP (1 mg/kg, ip), was administered to rats 30 min before starting behavioral tests Consecutively for 3 days. EtOAc-APV could attenuate SCOP-induced brain senescence in rats by improving behavioral performance and decreasing brain cell damage, which was associated with a notable reduction in AChE activity and MDA level, as well as an increase in SOD and GPx activities. Additionally, EtOAc-APV administration could reduce the expression of NF-KB and GFAP, which showed an anti-neuroinflammatory effect on the SLOP-treated rat. Overall, the current study highlights P. vulgaris L. as an antidementia dietary supplement.
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