Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 65, Issue 11, Pages 2315-2322Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b05679
Keywords
collagen; Gly-Pro-Hyp; Pro-Hyp; peptide; kinetics; dietary supplement
Funding
- fund for Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program in the Project for Developing Innovation System from Ministry of Education, Culture, Science and Technology
- Grants-in-Aid for Scientific Research [15K08138] Funding Source: KAKEN
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Collagen hydrolysate is a well-known dietary supplement for. the treatment of skin aging; however, its mode of action remains unknown. Previous studies have shown that the oral ingestion of collagen hydrolysate leads to elevated levels of collagen-derived peptides in the blood, but whether these peptides reach the skin remains unclear. Here, we analyzed the plasma concentration of collagen-derived peptides after ingestion of high tripeptide containing collagen hydrolysate in humans. We identified 17 types of collagen-derived peptides transiently, with a particular enrichment in Gly-Pro-Hyp. This was also observed using an in Vivo mouse. model in the plasma and skin, albeit with a higher enrichment of Pro-Hyp in the skin. Interestingly, this Pro-Hyp enrichment in the skin was derived from Gly-Pro-Hyp hydrolysis, as the administration of puce Gly-Pro-Hyp peptide led to similar results. Therefore, we propose that functional peptides can be transferred to the skin by dietary supplements of collagen.
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