Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 65, Issue 9, Pages 1984-1991Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b05773
Keywords
dispersive micro solid-phase extraction (dispersive micro SPE); sulfonamides; honey; milk; high-resolution mass spectrometry (HRMS); all ion fragmentation (AIF)
Funding
- National Nature Science of Foundation of China [21607035]
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A simple, rapid, sensitive, selective, and environmentally friendly method, based on a dispersive micro solid-phase extraction approach (dispersive micro SPE) coupled with liquid chromatography high-resolution mass spectrometry (LC-HRMS), was established for the analysis of sulfonamides in honey and milk. An efficient nontargeted screening strategy was designed to discover and identify known and unknown sulfonamides in honey and milk using full-MS/all ion fragmentation (AlF) mass spectrometry acquisition mode. The experimental parameters and conditions of dispersive micro SPE on extraction efficiency were optimized in detail. Under the optimized conditions, the dispersive micro SPE method showed a low limit of detection (LOD) for the targeted sulfonamides ranging from 0.003 to 0.2 mu g/L in milk and from 0.01 to 1 mu g/kg in honey with the recoveries of the analytes between 68.8 and 115.8%. Compared with the reported methods, improvements in convenience, low cost, and environmental friendliness were obtained in this study.
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