Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 65, Issue 26, Pages 5316-5321Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b02088
Keywords
Morus alba fruits; PCSK9 mRNA expression; isomoracin D; N-(N-phenzoyl-L-phenylalanyl)-L-phenylalanol; moracin C
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2015R1A2A201006736]
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Phytochemical investigation for a chloroform-soluble extract of dried Morus alba fruits, selected by proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression monitoring assay in HepG2 cells, led to the isolation of a new benzofuran, isomoracin D (1), and a naturally occurring compound, N-(N-benzoyl-L-phenylalanyl)-L-phenylalanol (2), along with 13 known compounds (3-15). All of the structures were established by NMR spectroscopic data as well as MS analysis. Of the isolates, moracin C (7) was found to inhibit PCSK9 mRNA expression with an IC50 value of 16.8 mu M in the HepG2 cells.
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