Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 65, Issue 41, Pages 9041-9053Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b02880
Keywords
caffeic acid phenethyl ester; insulin resistance; inflammation; JNK; NF-kappa B
Funding
- China Spark Program of Shanghai Municipal Agricultural Commission [(2014)-6-1-2]
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Caffeic acid phenethyl ester (CAPE), extracted from propolis, was evaluated for the ameliorative effects on insulin resistance and the mechanisms were identified, using non-insulin-dependent diabetes mellitus (NIDDM) model mice and insulin resistance (IR) model cells. After 5 weeks of CAPE supplementation, insulin sensitivity, hyperlipidemia, and peroxisome proliferator-activated receptor-alpha (PPAR-alpha) levels were improved in mice. Proinflammatory cytokines in serum and the expressions of tumor necrosis factor-alpha (TNF-alpha) mRNA in tissues were markedly downregulated from CAPE-treated mice. In vitro, CAPE supplement significantly improved glucose consumption, glucose uptake, glycogen content, and oxidative stress and decreased expression of glucose-6-phosphatase (G6Pase) mRNA in cells. Both in vivo and in vitro, CAPE enhanced p-Akt (Ser473) and p-insulin receptor substrate (IRS)-1 (Tyr612), but inhibited p-JNK (Thr183/Tyr185), p-NF-kappa B p65 (Ser536), and nuclear translocation of p-NF-kappa B p65 (Ser536). In summary, CAPE can ameliorate insulin resistance through modulation of JNK and NF-kappa B signaling pathway in mice and HepG2 cells.
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