Journal
TRENDS IN CANCER
Volume 6, Issue 5, Pages 407-418Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2020.02.006
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Funding
- National Institute of Health [R01NS106527, P30 CA042014, T32 DK007115]
- Huntsman Cancer Foundation
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Pediatric cancer is a leading cause of death idraw n children and adolescents. Improvements in pediatric cancer treatment that include the alleviation of longterm adverse effects require a deeper understanding of the genetic, epigenetic, and developmental factors driving these cancers. Here, we review how the unique attributes of the zebrafish model system in embryology, imaging, and scalability have been used to identify new mechanisms of tumor initiation, progression, and relapse and for drug discovery. We focus on zebrafish models of leukemias, neural tumors and sarcomas - the most common and difficult childhood cancers to treat.
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