Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 65, Issue 24, Pages 5000-5009Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b01844
Keywords
Lychee pulp phenolic extract; alcoholic liver disease; mitochondrial dysfunction; oxidative stress
Funding
- Joint Fund from the NSFC
- Guangdong Provincial Government [U1301211]
- National Nature Science Foundation of China [31501478, 31571828]
- PhD Start-up Fund of the Natural Science Foundation of Guangdong [2014A030310328]
- China Postdoctoral Science Foundation [2016M590764]
- Guangdong Provincial Science and Technology Project [2016B070701012, 2016A050503034]
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Mitochondria play an important role in the initiation and development of alcoholic liver disease (ALD). Our previous studies found lychee pulp phenolic extract (LPPE) exerted protective effect against ALD partly by inhibiting fatty acid beta-oxidation, and phenolic-rich lychee pulp extract improved restraint stress-induced liver injury by inhibiting mitochondrial dysfunction. The aim of this study was to investigate whether LPPE exerted protective effect against ALD via modulating mitochondrial function. The mice were treated with an ethanol-containing liquid diet alone or in combination with LPPE for 8 weeks. LPPE supplementation significantly alleviated hepatic steatosis, suppressed serum aspartate aminotransferase activity, and decreased triglyceride levels in serum and liver. On the basis of lipid peroxidation and antioxidant enzyme analyses, LPPE supplementation inhibited serum and hepatic oxidative stress. Moreover, LPPE supplementation significantly suppressed mitochondrial 8-hydroxy-2'-deoxyguanosine level, and increased mitochondrial membrane potential, mitochondrial DNA content, activities of mitochondrial complexes I and IV, and hepatic ATP level. Furthermore, LPPE supplementation significantly inhibited cytoplasmic cytochrome c level and caspase-3 activity, repressed Bax expression and Bax/Bcl-2 ratio, and increased Bcl-2 expression in liver. In summary, LPPE exerts beneficial effects against alcoholic liver injury by alleviating mitochondrial dysfunction.
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