Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 65, Issue 43, Pages 9443-9452Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b02965
Keywords
Arctii Fructus; arctigenin; allergic inflammation; mast cells; MAPK
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [NRF-2015R1C1A1A02036733, NRF-2016R1A2B2013921]
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The Arctium lappa seeds (Arctii Fructus) and its major active compound, arctigenin (ARC), are known to have anticancer, antiobesity, antiosteoporosis, and anti-inflammatory activities. However, the effect of Arctii Fructus and ARC on mast cell-mediated allergic inflammation and its associated mechanism have not been elucidated. Therefore, we attempted to investigate the antiallergic activity of Arctii Fructus and ARC on mast cells and experimental mouse models. Arctii Fructus water extract (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1 beta, IL-6, IL-8, and TNF-alpha in mast cells. AFW, AFE, and ARC inhibited phosphorylation of MAPKs and NF-kappa B in activated mast cells. Moreover, IgE-mediated passive cutaneous anaphylaxis and compound 48/80-induced anaphylactic shock were suppressed by AFW, AFE, and ARC administration. These results suggest that Arctii Fructus and ARC are potential therapeutic agents against allergic inflammatory diseases.
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