Journal
CHEMICAL SOCIETY REVIEWS
Volume 49, Issue 8, Pages 2273-2290Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cs00575g
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Funding
- National key research and development program of China [2018YFA0208900]
- National Basic Research Program of China [2015CB931802]
- National Science Foundation of China [31972927, 31700867, 81672937, 81974459, 81627901, 81803018, 81773653]
- PCSIRT [IRT13016]
- Scientific Research Foundation of Huazhong University of Science and Technology [3004170130]
- Program for HUST Academic Frontier Youth Team [2018QYTD01]
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Modulating nanomedicine mechanical properties for enhanced drug delivery to tumors has attracted increasing attention in the past few decades. In this tutorial review, we analyze the impact of nanomedicine mechanical properties on in vivo transport processes and highlight the most recent advances in drug delivery efficiency and antitumor efficacy. Typical nanoparticles that have been explored for this purpose since 2000 are summarized while the methods to tune and the techniques to characterize nanomedicine mechanical properties are introduced. In the end, challenges and perspectives on tailoring nanomedicine mechanical properties for tumor targeting delivery are discussed.
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