Journal
ACS APPLIED NANO MATERIALS
Volume 3, Issue 4, Pages 3625-3633Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.0c00335
Keywords
antimonene; supramolecular interactions; DNA recognition; biosensor; genetic diseases
Funding
- Ministerio de Ciencia Innovacion y Universidades [CTQ2017-84309-C2-1-R, MAT2016-77608-C3-1-P, PCI2018-093081, FIS2016-80434P, JTC2017/2D-SbGe]
- Generalitat Valenciana [APOSTD/2017/010]
- CAM [2017-T1/BIO5435]
- Maria de Maeztu Programme for Units of Excellence in RD [MDM-2014-0377]
- CAM (Grant TransNANOAVANSENS)
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Antimonene, a novel group 15 two-dimensional material, is functionalized with an oligonucleotide as a first step to DNA sensor development. The functionalization process leads to a few-layer antimonene modified with DNA that after deposition on gold screen-printed electrodes gives a simple and efficient DNA electrochemical sensing platform. We provide theoretical and experimental data of the DNA-antimonene interaction, confirming that oligonucleotides interact noncovalently but strongly with antimonene. The potential utility of this antimonene-based sensing device is assessed using, as a case of study, a sequence from the BRCA1 gene as the target DNA. The selectivity of the device allows not only recognition of a specific DNA sequence but also detection of a mutation in this gene associated with breast cancer, directly in clinical samples.
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