Journal
CYTOKINE
Volume 74, Issue 2, Pages 190-197Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.03.007
Keywords
Hepatitis C virus; NS3/4A; MAVS; Interferon; Innate immunity
Funding
- NIH/NIAID [K22 AI100935]
- Duke University Center for AIDS Research (CFAR), an NIH [5P30 AI064518]
- Duke School of Medicine Whitehead Scholarship
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Experimental studies on the interactions of the positive strand RNA virus hepatitis C virus (HCV) with the host have contributed to several discoveries in the field of antiviral innate immunity. These include revealing the antiviral sensing pathways that lead to the induction of type I interferon (IFN) during HCV infection and also the importance of type III IFNs in the antiviral immune response to HCV. These studies on HCV/host interactions have contributed to our overall understanding of viral sensing and viral evasion of the antiviral intracellular innate immune response. In this review, I will highlight how these studies of HCV/host interactions have led to new insights into antiviral innate immunity. Overall, I hope to emphasize that studying antiviral immunity in the context of virus infection is necessary to fully understand antiviral immunity and how it controls the outcome of viral infection. (C) 2015 Elsevier Ltd. All rights reserved.
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