Journal
DALTON TRANSACTIONS
Volume 49, Issue 16, Pages 5029-5033Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0dt00875c
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Funding
- National Natural Science Foundation of China [21977042, 31200642]
- Open Project Fund of Key Laboratory of Sustainable Development of Polar Fishery, Ministry of Agriculture and Rural Affairs of PRC [2019OPF01]
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Inspired by the structural features of native peroxidases, an artificial peroxidase was rationally designed using F43Y myoglobin with a Tyr-heme cross-link by further introduction of key residues, including both a distal Arg and a Trp close to the heme group, which exhibits an enhanced peroxidase activity similar to the most efficient native horseradish peroxidase. This study provides a simple approach for design of artificial heme enzymes by the combination of catalytic elements of native enzymes with the post-translational modifications of heme proteins.
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