Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 34, Pages 4668-4671Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc00449a
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Funding
- Medical Research Council (MRC) [MR/K022733/1]
- European Commission [316882]
- Department of Health via the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College London
- EPSRC [WT 203148/Z/16/Z]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [88887.185806/2018-00]
- Centre of Excellence in Medical Engineering - Wellcome Trust
- EPSRC [EP/S032789/1] Funding Source: UKRI
- MRC [MR/K022733/1] Funding Source: UKRI
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A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [C-11]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [C-11]CO2 delivery with a trapping efficiency of 21-89%.
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