Journal
CYTOGENETIC AND GENOME RESEARCH
Volume 147, Issue 1, Pages 1-9Publisher
KARGER
DOI: 10.1159/000441645
Keywords
Aneuploidy; Chromosome instability; Stem cells
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The potential use of stem cells (SCs) for tissue engineering, regenerative medicine, disease modeling, toxicological studies, drug delivery, and as in vitro model for the study of basic developmental processes implies large-scale in vitro culture. Here, after a brief description of the main techniques used for karyotype analysis, we will give a detailed overview of the chromosome abnormalities described in pluripotent (embryonic and induced pluripotent SCs) and somatic SCs, and the possible causes of their origin during culture. (C) 2015 S. Karger AG, Basel
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