4.7 Article

A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 41, Pages 5512-5515

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01800g

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Funding

  1. National Natural Science Foundation of China [91753122, 31961143004, 21672125]
  2. Major State Basic Research Development Program of China [2018YFA050760]

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We developed a host-guest ATP responsive strategy for efficient intracellular delivery of phosphopeptides, employing a pegylated arginine clustered calix[5]arene nanocarrier system that has great capability of recognizing the phosphate moieties on peptides and penetrating the cell membrane.

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