Journal
JORNAL BRASILEIRO DE PNEUMOLOGIA
Volume 43, Issue 5, Pages 373-379Publisher
SOC BRASILEIRA PNEUMOLOGIA TISIOLOGIA
DOI: 10.1590/S1806-37562016000000190
Keywords
Continuous positive airway pressure; Sleep apnea; obstructive; Hypertension; Meta-analysis
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Objective: To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). Methods: The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investigating the effects of CPAP on blood pressure in patients with resistant hypertension and OSA. The selected studies underwent quality assessment and meta-analysis, as well as being tested for heterogeneity. Results: Six randomized controlled trials were included in the meta-analysis. The pooled estimates of the changes in mean systolic blood pressure and mean diastolic blood pressure (as assessed by 24-h ambulatory blood pressure monitoring) were -5.40 mmHg (95% CI: -9.17 to -1.64; p = 0.001; I-2 = 74%) and -3.86 mmHg (95% CI: -6.41 to -1.30; p = 0.00001; I-2 = 79%), respectively. Conclusions: CPAP therapy can significantly reduce blood pressure in patients with resistant hypertension and OSA.
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