Journal
SOFT MATTER
Volume 16, Issue 17, Pages 4105-4109Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sm00387e
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Funding
- Science Engineering and Research Board (SERB) of India, Department of Science & Technology (DST) PURSE grant II of India [EMR/2016/007967]
- University Grant Commission (UGC), India
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A phenylalanine dimer assembly (Phe-DA) is reported as a basic constituent of a light emitting beta -amyloid type nanofibril network. The size and composition of the Phe-DA structure were characterized using various theoretical and experimental techniques. Further, the mechanism involved in the phenylalanine self-assembly process from Phe-DA to the nanofibril network was studied using optical spectroscopy and small angle X-ray scattering (SAXS). The discovery of Phe-DA and its unique optical properties may pave the way for design and development of novel theranostics against metabolite based pathalogical disorders. Further, the role of the Phe-DA structure as the elementary unit in the formation of a long range assembly structure may provide vital understanding for the development of functional materials using simple organic molecules.
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