Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 43, Pages 5718-5734Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01771j
Keywords
-
Categories
Funding
- Foundation for Polish Sciences [FNP TEAM POIR.04.04.00-00-4232/17-00]
Ask authors/readers for more resources
Strain-release driven transformations give access to attractive bioisosteric motifs highly prized by medicinal chemists and they are characteristic of molecules possessing distorted bond lengths and angles. By broadening the chemical space in drug discovery, recently, these compounds have attracted a lot of interest. Their reactivity stems mainly from an increased energy and destabilization. As a result, the opening of the bridging bond occurs under the action of both nucleophiles and electrophiles as well as radical species and transition metals. Though the bridge bond dominates their reactivity, it is also influenced by the substitution pattern. This feature article focuses on strain-release driven strategies paying particular attention to the most recent (year > 2010) advances.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available