Journal
LAB ON A CHIP
Volume 20, Issue 9, Pages 1621-1627Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0lc00304b
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Funding
- National Science Foundation (NSF) [1534126]
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1534126] Funding Source: National Science Foundation
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Rapid, sensitive and specific detection and reporting of infectious pathogens is important for patient management and epidemic surveillance. We demonstrated a point-of-care system integrated with a smartphone for detecting live virus from nasal swab media, using a panel of equine respiratory infectious diseases as a model system for corresponding human diseases such as COVID-19. Specific nucleic acid sequences of five pathogens were amplified by loop-mediated isothermal amplification on a microfluidic chip and detected at the end of reactions by the smartphone. Pathogen-spiked horse nasal swab samples were correctly diagnosed using our system, with a limit of detection comparable to that of the traditional lab-based test, polymerase chain reaction, with results achieved in similar to 30 minutes.
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