Journal
CURRENT OPINION IN BIOMEDICAL ENGINEERING
Volume 14, Issue -, Pages 59-66Publisher
ELSEVIER
DOI: 10.1016/j.cobme.2020.05.009
Keywords
Stretch growth; Directional scaffolding; Mechanotransduction; Nerve growth; Nerve development; Durotaxis; Tension
Categories
Funding
- NSF CAREER award [CBET-0747615]
Ask authors/readers for more resources
Forces and displacements play essential roles in the development and maintenance of all living organisms. The biomechanics in living systems includes traction in cell motility, motor proteins driving cellular transport, tensegrity of the cytoskeleton, and mechanotransduction of signal pathways. In the past few decades, we have learned a great deal about how biomechanics is important in the development, maintenance, and repair of the nervous system. In this review, we critically assess recent advances in using mechanical stimuli toward exploiting the directed growth and formation of nervous tissues. We discuss current systems that recapitulate the mechanical environment surrounding neural tissues as engineering solutions to explore the relationship forces play in modifying neurons and their processes, as well as exploit these processes to enhance regeneration and repair.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available