Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 19, Issue 6, Pages 776-782Publisher
SPRINGERNATURE
DOI: 10.1039/d0pp00098a
Keywords
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Funding
- JSPS KAKENHI [17H03085]
- Asahi Glass Foundation
- Grants-in-Aid for Scientific Research [17H03085] Funding Source: KAKEN
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Ultrafast reversible DNA/RNA photo-cross-linking is a powerful tool for regulating the target strand in living cells. In particular, 3-cyanovinylcarbazole (K-CNV) and 3-cyanovinylcarbazole modified byd-threoninol (D-CNV) can photo-cross-link to pyrimidine bases within a few seconds of photoirradiation. However, these photo-cross-linkers can only cross-link to the counter base if it is adjacent to the 5 '-side (-1 position). In this study, we synthesized novel photo-cross-linkers with varying linker lengths capable of photo-cross-linking with pyrimidine bases at locations other than the -1 positionviaclick chemistry. The photo-cross-linking site was dependent on linker length.
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