Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 15, Issue 17, Pages 1743-1749Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150427125033
Keywords
Antitumoral; Azorella madreporica; Chalcone; Diterpenes; Docking; Yareta
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Funding
- Fondecyt project [1120199]
- project PIEI-Quim-Bio, University of Talca
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Phytochemical investigation of Azorella madreporica led to the isolation of four known compounds and an unknown chalcone. The structure of the new compound was identified by spectroscopy, including two-dimensional NMR techniques and comparison with published spectral data. The antioxidant activity of chalcone (compound 1) was measured using the 1,2-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay, and the bioactivity was evaluated against five bacteria (Mycobacterium smegmatis ATCC 14468, clinical isolates of Staphylococcus aureus, Klebsiella granulomatis, Morganella morganii and Escherichia coli) and four cancer cell lines. Docking studies with the tested cancer related proteins revealed nearby values of energy between doxorubicin and compound 1. Besides, protein-ligand interactions correlate with these energy values.
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