Journal
JACC-CARDIOVASCULAR INTERVENTIONS
Volume 10, Issue 20, Pages 2064-2075Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcin.2017.09.001
Keywords
chronic kidney disease; dialysis; renal replacement therapy; transcatheter aortic valve replacement
Categories
Funding
- Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) National Cardiovascular Data Registry (NCDR) (STS/ACC TVT registry)
- American College of Cardiology
- Society of Thoracic Surgeons
- Abbott Vascular
- PCORI (Patient Centered Outcomes Research Institute)
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OBJECTIVES The authors sought to elucidate the true incidence of renal replacement therapy (RRT) after transcatheter aortic valve replacement (TAVR). BACKGROUND There is a wide discrepancy in the reported rate of RRT after TAVR (1.4% to 40%). The true incidence of RRT after TAVR is unknown. METHODS The STS/ACC TVT (Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy) registry was linked to the Centers for Medicare & Medicaid database to identify all patients that underwent TAVR from November 2011 through September 2015 and their outcomes. The authors compared rates of death, new RRT, and a composite of both as a function of pre-procedure glomerular filtration rate (GFR), both in stages of chronic kidney disease (CKD), as well as on a continuous scale. RESULTS Pre-procedure GFR is associated with the risk of death and new RRT after TAVR when GFR is<60 ml/min/m(2), and increases significantly when GFR falls below 30 ml/min/m(2). Incremental increases in GFR of 5 ml/min/m(2) were statistically significant (unadjusted hazard ratio: 0.71; p<0.001) at 30 days, and continued to be significant at 1 year when pre-procedure GFR was < 60ml/min/m(2). One in 3 CKDstage 4 patients will be dead within 1 year, with 14.6% (roughly 1 in 6) requiring dialysis. In CKD stage 5, more than one-third of patients will require RRT within 30 days; nearly two-thirds will require RRT at 1 year. CONCLUSIONS In both unadjusted and adjusted analysis, pre-procedural GFR was associated with the outcomes of death and new RRT. Increasing CKD stage leads to an increased risk of death and/or RRT. Continuous analysis showed significant differences in outcomes in all levels of CKD when GFR was <60 ml/min/m(2). Pre-procedure GFR should be considered when selecting CKD patients for TAVR. (C) 2017 by the American College of Cardiology Foundation.
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