Journal
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
Volume 7, Issue 3, Pages 152-157Publisher
SPRINGER BASEL AG
DOI: 10.14283/jpad.2020.18
Keywords
Alzheimer's disease; dementia; tau; tauopathy; neurotrophins; neuroinflammation; lifestyle intervention; photobiomodulation; neurostimulation; geroscience
Categories
Funding
- TauRx
- NIA
- FNIH
- Alzheimer's Association
- Eisai
- Roche
- Lundbeck
- Avanir
- Grifols
- Nutricia
- Otsuka
- Samumed
- Suven, United Neuroscience pharmaceutical
- Alzheimer Drug Discovery Foundation
- United Neuroscience
- NIH
- Eli Lilly
- Allergan
- vTV Therapeutics
- Sanofi
- Neurotrope
- Avraham, Ltd
- Boehringer Ingelheim
- Neurim, Ltd
- Neuronix, Ltd
- Takeda
- vTv
- Roche/Genentech
- Abbott
- Washington Univ/NIA DIAN-TU
- BioXcel
- Gerontological Society of America
- Abbvie
- Genentech
- Lilly
- Merck Co
- Arizona Department of Health Services
- National Institute on Aging
- Alzheimer's Disease Neuroimaging Initiative (ADNI)
- Merck
- European Commission
Ask authors/readers for more resources
While amyloid-targeting therapies continue to predominate in the Alzheimer's disease (AD) drug development pipeline, there is increasing recognition that to effectively treat the disease it may be necessary to target other mechanisms and pathways as well. In December 2019, The EU/US CTAD Task Force discussed these alternative approaches to disease modification in AD, focusing on tau-targeting therapies, neurotrophin receptor modulation, anti-microbial strategies, and the innate immune response; as well as vascular approaches, aging, and non-pharmacological approaches such as lifestyle intervention strategies, photobiomodulation and neurostimulation. The Task Force proposed a general strategy to accelerate the development of alternative treatment approaches, which would include increased partnerships and collaborations, improved trial designs, and further exploration of combination therapy strategies.
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