Journal
THERANOSTICS
Volume 10, Issue 15, Pages 6629-6637Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.47849
Keywords
charge conversion; zwitterionic; polyprodrug; triggered drug release; nanomedicine
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Funding
- National Natural Science Foundation of China [81971621, 81671707]
- Natural Science Foundation of Guangdong Province [2019A1515012212, 2018A030313678]
- Research Fund for Lin He's Academician Workstation of New Medicine and Clinical Translation
- Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [ZICEB000087] Funding Source: NIH RePORTER
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Zwitterionic surface modification is a promising strategy for nanomedicines to achieve prolonged circulation time and thus effective tumor accumulation. However, zwitterion modified nanoparticles suffer from reduced cellular internalization efficiency. Methods: A polyprodrug-based nanomedicine with zwitterionic-to-cationic charge conversion ability (denoted as ZTC-NMs) was developed for enhanced chemotherapeutic drug delivery. The polyprodrug consists of pH-responsive poly(carboxybetaine)-like zwitterionic segment and glutathione-responsive camptothecin prodrug segment. Results: The ZTC-NMs combine the advantages of zwitterionic surface and polyprodrug. Compared with conventional zwitterionic surface, the ZTC-NMs can respond to tumor microenvironment and realize ZTC surface charge conversion, thus improve cellular internalization efficiency of the nanomedicines. Conclusions: This ZTC method offers a strategy to promote the drug delivery efficiency and therapeutic efficacy, which is promising for the development of cancer nanomedicines.
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