Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 17, Issue 8, Pages 1095-1101Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.44439
Keywords
cancer; colon; cyclooxygenase-2; invasion; prostaglandin
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Colorectal cancer is the third common cancer in this world, accounting for more than 1 million cases each year. However, detailed etiology and mechanism of colorectal cancer have not been fully understood. For example, cyclooxygenase-2 (COX-2) and its product prostaglandin E-2(PGE(2)) have been closely linked to its occurrence, progression and prognosis. However, the mechanisms on how COX-2 and PGE(2)-mediate the pathogenesis of colorectal cancer are obscure. In this review, we have summarized recent advances in studies of pathogenesis and control in colorectal cancer to assist further advances in the research for the cure of the cancer. In addition, the knowledge gained may also guide the audiences for reduction of the risk and control of this deadly disease.
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