Journal
ISME JOURNAL
Volume 11, Issue 5, Pages 1286-1290Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ismej.2016.200
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Funding
- F30 NIDCR fellowship [1F30DE024917-01A1]
- Burroughs Wellcome Fund
- National Institute of Environmental Health Sciences, National Institutes of Health [P30-ES002109]
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Mucus forms a major ecological niche for microbiota in various locations throughout the human body such as the gastrointestinal tract, respiratory tract and oral cavity. The primary structural components of mucus are mucin glycoproteins, which crosslink to form a complex polymer network that surrounds microbes. Although the mucin matrix could create constraints that impact inhabiting microbes, little is understood about how this key environmental factor affects interspecies interactions. In this study, we develop an experimental model using gel-forming human salivary mucins to understand the influence of mucin on the viability of two competing species of oral bacteria. We use this dual-species model to show that mucins promote the coexistence of the two competing bacteria and that mucins shift cells from the mixed-species biofilm into the planktonic form. Taken together, these findings indicate that the mucus environment could influence bacterial viability by promoting a less competitive mode of growth.
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