Journal
RENAL FAILURE
Volume 42, Issue 1, Pages 323-328Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/0886022X.2020.1745235
Keywords
Diabetic kidney disease; chronic kidney disease; apolipoprotein B; renal replacement therapy
Categories
Funding
- Science and Technology Planning Project Foundation of Guangdong Province [2016A020215071]
- Medical Scientific Research Foundation of Guangdong [A2016227]
Ask authors/readers for more resources
Objective: Few studies have investigated the association of apolipoprotein B (ApoB) with the progression of diabetic kidney disease (DKD) and the risk of renal replacement therapy (RRT). Method: In this retrospective cohort study, a group of 258 DKD patients with stage 3-5chronic kidney disease(CKD)were divided into low ApoB (<1.1 g/L) and high ApoB (>= 1.1 g/L) groups and followed-up for 20.51 +/- 6.11 months. The association of the serum ApoB concentration with RRT was determined by Kaplan-Meier and Cox regression analysis. ApoB was measured in the serum. Results: Ninety-three of the 258 DKD patients needed RRT during follow-up. Kaplan-Meier analysis showed that patients with high ApoB were significantly more likely to progress to RRT than those with low ApoB (log-rank = 16.62, p < 0.001). The presence of high ApoB increased the risk of RRT. Analysis of ApoB as either a categorical (<1.1 g/L or >= 1.1 g/l) or continuous variable by univariate and multivariate regression found that ApoB was an independent risk factor of DKD progression to RRT in this group of DKD patients with stage 3-5 CKD (p < 0.05). Conclusion: Increased ApoB was an independent predictor of progression to RRT. A larger study is needed to confirm the unfavorable prognosis of increased ApoB in DKD patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available